PUBLICATIONS

Bhattacharyya R, Walker M, Boykin R, Son S, Liu J, Hachey A, et al. (2019). Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA. Scientific Reports. 9. doi:10.1038/s41598-019-40792-3. [PubMed]

Betin V, Penaranda C, Bandyopadhyay N, Yang R, et al. (2019). Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis. Scientific Reports. 9. doi:10.1038/s41598-019-55633-6. [PubMed]

Bhattacharyya R, Bandyopadhyay N, Ma P, Son S, Liu J, He L, et al. (2019). Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination. Nature Medicine. 25. 1-7. doi:10.1038/s41591-019-0650-9. [PubMed]

Johnson E, Office E, Kawate T, Orzechowski M, Hung DT. (2019). Large-scale chemical-genetic strategy enables design of antimicrobial combination chemotherapy in Mycobacteria. ACS Infectious Diseases. 6 (1), 56-63. doi:10.1021/acsinfecdis.9b00373. [PubMed]

Johnson E, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez J, Audette R, et al. (2019). Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes. Nature. 571. doi:10.1038/s41586-019-1315-z. [PubMed]

Romano K, Warrier T, Poulsen B, Nguyen P, Loftis A, Saebi A, Pentelute B, Hung DT. (2019). Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 63. doi:10.1128/AAC.00511-19. [PubMed]

Poulsen B, Yang R, Clatworthy A, White T, et al. (2019). Defining the core essential genome of Pseudomonas aeruginosa. PNAS. 116. doi:10.1073/pnas.1900570116. [PubMed]

Penaranda C & Hung DT. (2019). Single-Cell RNA Sequencing to Understand Host–Pathogen Interactions. ACS Infectious Diseases. 5. doi:10.1021/acsinfecdis.8b00369. [PubMed]

Parada Kusz M, Penaranda C, Hagedorn E, Clatworthy A, et al. (2018). Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease Models & Mechanisms. 11. doi:10.1242/dmm.034876. [PubMed]

Fang C, Lee K, Nietupski R, Bates R, Fernandez R, et al. (2018). Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors. Bioorganic & Medicinal Chemistry Letters. 28. doi:10.1016/j.bmcl.2018.09.037. [PubMed]

Ma P, Laibinis H, Ernst C, Hung DT. (2018). Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate. Antimicrob. Agents Chemother. 62. doi:10.1128/AAC.01281-18. [PubMed]

Bhattacharyya R, Thakku SG, Hung DT. (2018). Harnessing CRISPR Effectors for Infectious Disease Diagnostics. ACS Infectious Diseases. 4. doi:10.1021/acsinfecdis.8b00170. [PubMed]

Clatworthy A, Romano K, Hung DT. (2018). Whole-organism phenotypic screening for anti-infectives promoting host health. Nat. Chem. Biol. 14. doi:10.1038/s41589-018-0018-3. [PubMed]

Wellington S & Hung DT. (2018). The Expanding Diversity of Mycobacterium tuberculosis Drug Targets. ACS Infectious Diseases. 4. doi:10.1021/acsinfecdis.7b00255. [PubMed]

Bhattacharyya R, Liu J, Ma P, Bandyopadhyay N, Livny J, Hung DT. (2017). Rapid Phenotypic Antibiotic Susceptibility Testing Through RNA Detection. Open Forum Infect. Dis. 4. S33-S33. doi:10.1093/ofid/ofx162.082. [PMC]

Wellington S, Nag P, Michalska K, Johnston S, Jedrzejczak R, et al. (2017). A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol. 13. doi:10.1038/nchembio.2420. [PubMed]

Barczak A,  Avraham R, Singh S, Luo S, Zhang W, Bray MA, et al. (2017). Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. PLoS pathogens. 13. doi: 10.1371/journal.ppat.1006363. [PubMed]

Gomez J, Kaufmann-Malaga B,  Wivagg C, Kim P, Silvis M, Renedo N, Ioerger T, Ahmad R, Livny J, Fishbein S, Sacchettini J, Carr S, Hung DT. (2017). Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. eLife. 6. doi:10.7554/eLife.20420. [PubMed]

Avraham R & Hung DT (2016). A perspective on single cell behavior during infection. Gut microbes. 7. doi:10.1080/19490976.2016.1239001. [PMC]

Zhang D, Gomez J, Chien JY, Haseley N, Desjardins C, Earl A, Hsueh PR, Hung DT. (2016). Genomic Analysis of the Evolution of Fluoroquinolone Resistance in Mycobacterium tuberculosis Prior to Tuberculosis Diagnosis. Antimicrob. Agents Chemother. 60. doi:10.1128/AAC.00664-16. [PubMed]

Outterson K, Rex JH, Jinks T, et al. Accelerating global innovation to address antibacterial resistance: introducing CARB-X. Nat Rev Drug Discov. 2016;15(9):589-90. doi:10.1038/nrd.2016.155. [PubMed]

Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT. A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes. Nat Protoc. 2016;11(8):1477-91. doi:10.1038/nprot.2016.090. [PubMed]

Grant SSchmidt, Wellington S, Kawate T, et al. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chem Biol. 2016;23(6):666-77. doi:10.1016/j.chembiol.2016.05.011. [PubMed]

Avraham R, Haseley N, Brown D, et al. Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses. Cell. 2015;162(6):1309-21. doi:10.1016/j.cell.2015.08.027. [PubMed]

Wivagg CN, Bhattacharyya RP, Hung DT. Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis. J Antibiot (Tokyo). 2014;67(9):645-54. doi:10.1038/ja.2014.94. [PubMed]

Stanley SA, Barczak AK, Silvis MR, et al. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014;10(2):e1003946. doi:10.1371/journal.ppat.1003946. [PubMed]

Slater LH, Clatworthy AE, Hung DT. Bacterial toxins and small molecules elucidate endosomal trafficking. Trends Microbiol. 2014;22(2):53-5. doi:10.1016/j.tim.2013.12.002. [PubMed]

Kawate T, Iwase N, Shimizu M, et al. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorg Med Chem Lett. 2013;23(22):6052-9. doi:10.1016/j.bmcl.2013.09.035. [PubMed]

Grant SSchmidt, Kawate T, Nag PP, et al. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem Biol. 2013;8(10):2224-34. doi:10.1021/cb4004817. [PubMed]

Stanley SA, Kawate T, Iwase N, et al. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013;110(28):11565-70. doi:10.1073/pnas.1302114110. [PubMed]


Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013;110(24):9932-7. doi:10.1073/pnas.1302257110. [PubMed]

Hett EC, Slater LH, Mark KG, et al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013;9(6):398-405. doi:10.1038/nchembio.1236. [PubMed]


Grant SS, Hung DT. Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence. 2013;4(4). doi:10.4161/viru.23987. [PubMed]

Chand NS, Clatworthy AE, Hung DT. The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence. J Bacteriol. 2012;194(23):6537-47. doi:10.1128/JB.01168-12. [PMC]

Stanley SA, Grant SSchmidt, Kawate T, et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7(8):1377-84. doi:10.1021/cb300151m. [PubMed]

Grant SSchmidt, Kaufmann BB, Chand NS, Haseley N, Hung DT. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proc Natl Acad Sci U S A. 2012;109(30):12147-52. doi:10.1073/pnas.1203735109. [PubMed]

Barczak AK, Gomez JE, Kaufmann BB, et al. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012;109(16):6217-22. doi:10.1073/pnas.1119540109. [PubMed]

Chand NS, Lee JSee-Wai, Clatworthy AE, Golas AJ, Smith RS, Hung DT. The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. J Bacteriol. 2011;193(12):2989-99. doi:10.1128/JB.01546-10. [PubMed]

Stanley SA, Hung DT. Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 2009;48(37):8776-86. doi:10.1021/bi9009083. [PubMed]

Clatworthy AE, Lee JSee-Wai, Leibman M, Kostun Z, Davidson AJ, Hung DT. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect Immun. 2009;77(4):1293-303. doi:10.1128/IAI.01181-08. [PubMed]

Clatworthy AE, Pierson E, Hung DT. Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol. 2007;3(9):541-8. doi:10.1038/nchembio.2007.24. [PubMed]

Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006;10(4):321-6. doi:10.1016/j.cbpa.2006.06.016. [PubMed]

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005;310(5748):670-4. doi:10.1126/science.1116739. [PubMed]

Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A. 2005;102(8):3028-33. doi:10.1073/pnas.0409559102. [PNAS]

Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol. 1996;3(4):287-93. doi:10.1016/s1074-5521(96)90108-8. [PubMed]